US genetic map research will re-＂classify＂ cancer
US genetic map research will re-"classify" cancer
Xinhua News Agency, Washington, April 5 (Reporter Zhou Zhou) Funded scientists funded by the National Health Research Institute completed the large-scale cancer genome map, and they proposed according to the similarity of gene variation and expression, and propose to categorize the cancer by molecular type ".
Researchers believe that this will provide new ideas for cancer diagnosis and treatment.
On the 5th, it was published in the US "Cell" magazine in the United States, analyzed 33 genes, apparent genetic and proteomic changes of 30,000 cancers, and confirmed about 300 genes that caused cancer, and found already The approved therapy covers a gene mutation of more than half of the tumor cases. The large-scale study of "cancer genomic map" initiated in 2005, originated from the same cell species or a cancer that occurred in different organs of the same system, and similarity between each other. Examples of the researchers say that the head, neck, pulmonary, esophagus, bladder and cervical squamous cell carcinoma have strong molecular similarity, can be somed to one; gastric cancer, colon cancer and rectal cancer, etc. belong to the same system Cancer also has molecular similarity.
Instead, although some cancers have occurred in the same organ, they may belong to a completely different molecular subtype, such as kidney cancer. Ding Li, a common author of the papers, the University of St. Louis Washington, USA, said that for some cancers, we have been treated with completely different diseases, which is the first time to summarize genetics behind 33 kinds of cancer, induction Summarize. The papers are common, and the University of North Carolina, the University of North Carolina, Charles Peru, said: "The new classification system on the molecular level is very helpful for clinical, and some similar clinical manifestations of different site tumors can be explained." Cristo Grestopher Benz said that cancer genome map data can provide hope for developing anti-cancer new therapies, including immunotherapy for significant effective effects of a few cancers.
"When you rewrite cancer textbooks, the cancer classification has occurred paradigm conversion, and it is necessary to break the past clinical incology." Benz said.